Cellulitis without associated purulent drainage or abscess
Outpatient treatment recommendations:
- Dicloxacillin 500 mg PO q6h for 10-14d or
- Cephalexin 500 mg PO q6h for 10-14d or
- Amoxicillin-clavulanate 875 mg/125 mg PO BID for 10-14d
Inpatient treatment recommendations:
- Cefazolin 1 g IV q8h for 1-3d
Cellulitis with purulent drainage and/or abscess
Outpatient treatment recommendations (coverage against CA-MRSA):
- Doxycycline 100 mg PO BID for 10-14d (not for use in pregnant women or in children)
- Clindamycin 300-600 mg PO q8h for 10-14d
- Trimethoprim-sulfamethoxazole (160 mg/800 mg) DS 2 tabs PO BID for 10-14d
Inpatient treatment recommendations:
- Vancomycin 15 mg/kg IV q12h for 1-3d
Empiric therapy for mammalian bite wounds
Outpatient treatment recommendations:
- Amoxicillin-clavulanate 875 mg/125 mg PO BID for 10-14d or
- Doxycycline 100 mg PO BID for 10-14d or
- Cephalexin 500 mg TID for 10-14d
Inpatient treatment recommendations:
- Ampicillin-sulbactam 3 g IV q6h for 1-3d; then transition to oral medication or
- Cefazolin 1 g q8h for 1-3d
Diabetic foot ulcers
Outpatient treatment recommendations:
- Clindamycin 300-600 mg PO q8h for 10-14d
Inpatient treatment recommendations:
- Piperacillin-tazobactam 3.375 g IV q6h for 1-3d
Failure of empiric therapy
Reassess for unusual elements of history that suggest an unusual cause, such as injury in water (salt or fresh), immunocompromise, or bite wound
http://emedicine.medscape.com/article/2012280-overview